Ideas of Order for Amyloid Fibril Structure
β Scribed by Ronald Wetzel
- Book ID
- 114329134
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 269 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0969-2126
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## Abstract Amyloid fibrils are deposited in a number of diseases, including Alzheimer's disease, Type 2 diabetes, and the transmissible spongiform encephalopathies (TSE). These insoluble deposits are formed from normally soluble proteins that assemble to form fibrous aggregates that accumulate in
Amyloid fibrils are intrinsically noncrystalline, insoluble, high-molecular-weight aggregates of peptides and proteins, with considerable biomedical and biophysical significance. Solid-state NMR techniques are uniquely capable of providing high-resolution, site-specific structural constraints for am