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Icariin induces mouse embryonic stem cell differentiation into beating functional cardiomyocytes

✍ Scribed by Xiaodong Sun; Xiuwei Sun; Xiudong Jin; Xiaoli Zhang; Chunling Liu; Lei Lei; Lianhong Jin; Huiwen Liu

Publisher
Springer
Year
2010
Tongue
English
Weight
479 KB
Volume
349
Category
Article
ISSN
0300-8177

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The cardiomyocyte (CM) differentiation of embryonic stem cells (ESCs) is routinely cultured as two-dimensional (2D) monolayer, which doesn't mimic in vivo physiological environment and may lead to low differentiated level of ESCs. Here, we develop a novel strategy that enhances CM differentiation of