Ibuprofen induced drug loaded polymeric micelles

✍ Scribed by Song Wei Tan; Hong Jun Wang; Ke Hua Tu; Hong Liang Jiang; Li Qun Wang

• Book ID: 104010606
• Publisher: Chinese Electronic Periodical Services
• Year: 2011
• Tongue: English
• Weight: 321 KB
• Volume: 22
• Category: Article
• ISSN: 1001-8417
• DOI: 10.1016/j.cclet.2011.04.005

✦ Synopsis

Three model drugs with different function groups were chosen to dialyze with dextran-graft-poly (N-isopropylacrylamide). Only ibuprofen could induce the formation of drug loaded micelles, which was confirmed with dynamic light scattering and transmission electron microscope. Hydrogen-bonding between the amide groups of poly (N-isopropylacrylamide) and the carboxyl groups of ibuprofen was driving force for the drug-loaded micelle. It was also found that the diameter of the ibuprofen-loaded micelles changed reversibly against temperature.