Computer programing has become an essential tool for processing experimental data. An excellent discussion of IBM-Fortran programing has been presented by McCracken (1) and McCracken and Dorn (2); and, in recent years, several papers on the processing of enzyme kinetic data have appeared (3). Bethune and Kegeles (4) have utilized a computer program for numerical determinations of reversibly interacting systems. The objective of this paper is to describe a computer program for the determination of sedimentation and diffusion coefficients, molecular weights, and for algebraic: boundary analysis (5,6) from measurements made on schlieren patterns. Use of such a computer program makes possible the accurate computation of schlieren parameters wit,h a minimum of time and error while providing a means of standardizing calculation procedures among different laboratories. The program can be easily modified to allow for variation in schlieren optical constants. CALCULATION PROCEDURE IBM Computer Programing IBM-Fortran digital computers 1622 and 1620, model 2, were used to compute all physical constants from measurements made on schlieren patterns. Data which relate theory to computer calculations for the determination of ultracentrifuge parameters are presented.