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Iatrogenic origins of depression in the elderly. Is medication a significant aetiologic factor in geriatric depression? Considerations and a preliminary approach

✍ Scribed by Dr. A. D. F. Dhondt; C. Hooijer

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 544 KB
Volume: 10
Category: Article
ISSN: 0885-6230
DOI: 10.1002/gps.930100102

No coin nor oath required. For personal study only.

✦ Synopsis

If depressed mood can occur as a side-effect of drugs prescribed for other purposes, its frequency will rise in the elderly. The significance of this drug associated depression (DAD) in the elderly should be considered.

DOES DRUG ASSOCIATED DEPRESSION EXIST?

The first, qualitative question is whether drugs prescribed for other diseases can have depression as a side-effect. Freis (1954) described five cases of DAD following the use of reserpine, one of the first case reports. Further evidence on the probability of a causal relationship emerged in numerous case reports of depression as a side-effect of a specific drug. Part of this evidence depends on a correlation between prevalence of depression and drug use, part on the sequential incidence of prescription of the drug and incidence of depression and part on theoretical pharmacological considerations. This drugoriented approach has converged into an impressive body of knowledge, crystallized in reviews (Ganzini et al., 1993) and pharmacopeia. One prominent representative of this approach is the authoritative book series Meyler's Side Efsects of Drugs (Dukes, 1988) and the Side Efsects ofDrugs Annuals (Dukes, 1989-1 991). Panels of authorities carefully reviewed the existing evidence on side-effects of specific drugs. In about half of the chapters depression is actually mentioned as a side-effect

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