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I-84 Gene therapy of chronic hepadnavirus infection

โœ Scribed by J. Prieto; J. Crettaz; G. Gonzalez-Aseguinolaza


Book ID
118616805
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
52 KB
Volume
12
Category
Article
ISSN
1201-9712

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To investigate host and viral mechanisms determining hepadnaviral persistence and hepatocarcinogenesis, we developed a mouse model by transplanting woodchuck hepatocytes into the liver of mice that contain the urokinase-type plasminogen activator transgene (uPA) and lack mature B and T lymphocytes d