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I-125-LIZAC, a novel ligand binding with high affinity to 5-HT-3 CNS receptors

✍ Scribed by W.A. Hewlett; T. de Paulis; D.E. Schmidt; B.L. Trivedi; N.S. Mason; M.H. Ebert

Book ID: 118857997
Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 123 KB
Volume: 37
Category: Article
ISSN: 0006-3223
DOI: 10.1016/0006-3223(95)94681-l

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We have prepared (S)-5-chloro-3-[ 1251]iodo-2-methoxy-N-( l-azabicyclo[2.2.2]oct-3-yl)benzamide ([125I]DAIZAC, [ 1254-3) as a radioligand for characterization of the 5-HT-3 receptor. Preparation of the 3-tri-n-butylstannyl precursor was accomplished from the corresponding unlabeled DAIZAC by reactio