I-125 and I-123 labelled iodobenzyl bromide, a useful alkylating agent for radiolabelling biologically important molecules
✍ Scribed by Alan A. Wilson; Robert F. Dannals; Hayden T. Ravert; H. Donald Burns; Henry N. Wagner Jr.
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- French
- Weight
- 426 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
✦ Synopsis
The radioiodination of 4-trimethylsilylbenzyl bromide in acetic acid with no carrier added 1-125 and 1-123 iodide ion and N-chlorosuccinimide (NCS) is a rapid, high yielding process which produces high specific activity 4-[I-125 or I-123liodobenzyl bromide. alkylating agent has been efficiently reacted with N,N-dimethylaniline and triphenylphosphine to generate radiolabelled quaternary amnonium and phosphonium salts, and should be useful for labelling other biologically important molecules which possess suitable nucleophilic functional groups.