Hypoxic induction of HIF-1α and VEGF expression in head and neck squamous cell carcinoma lines is mediated by stress activated protein kinases
✍ Scribed by Babak Shemirani; David L Crowe
- Book ID
- 114393800
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 208 KB
- Volume
- 38
- Category
- Article
- ISSN
- 1368-8375
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## Abstract The HIF‐1α protein plays a key role in the cellular response to hypoxia via transcriptional regulation of genes involved in erythropoiesis, angiogenesis, and metabolism. Overexpression of HIF‐1α is commonly found in solid tumors in significant association with increased patient mortalit
## Abstract We previously reported that expression of angiogenesis factors interleukin‐8 (IL‐8) and vascular endothelial growth factor (VEGF) is promoted by coactivation of transcription factors nuclear factor‐kappaB (NF‐κB) and activator protein‐1 (AP‐1) by interleukin‐1α in human head and neck sq