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Hypoxia-Specific Downregulation of Endogenous Human VEGF-A Gene by Hypoxia-Driven Expression of Artificial Transcription Factor

✍ Scribed by Tomoaki Mori; Jun Sasaki; Yasuhiro Aoyama; Takashi Sera


Book ID
107581830
Publisher
Humana Press Inc
Year
2010
Tongue
English
Weight
391 KB
Volume
46
Category
Article
ISSN
1073-6085

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## Abstract ## BACKGROUND Previous reports indicate that Genistein, a naturally occurring isoflavonoid, exhibits strong antiangiogenic activity. The underlying mechanism of inhibition, however, remains unclear. Among the biologic effects of Genistein are the inhibition of tyrosine kinases and the