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Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1α

✍ Scribed by Soeda, A; Park, M; Lee, D; Mintz, A; Androutsellis-Theotokis, A; McKay, R D; Engh, J; Iwama, T; Kunisada, T; Kassam, A B

Book ID: 109971056
Publisher: Nature Publishing Group
Year: 2009
Tongue: English
Weight: 616 KB
Volume: 28
Category: Article
ISSN: 0950-9232
DOI: 10.1038/onc.2009.252

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## Abstract Ascochlorin, a non‐toxic prenylphenol compound derived from the fungus __Ascochyta viciae__, has been shown recently to have anti‐cancer effects on various human cancer cells. However, the precise molecular mechanism of this anti‐cancer activity remains to be elucidated. Here, we invest