Hypoxia-inducible factor-1 drives the motility of the erythroid progenitor cell line, UT-7/Epo, via autocrine motility factor

Thrombin induces expression of twist and

Thrombin induces expression of twist and cell motility via the hypoxia-inducible factor-1α translational pathway in colorectal cancer cells

✍ Li-Hsun Chang; Chun-Han Chen; Der-Yi Huang; Hui-Chen Pai; Shiow-Lin Pan; Che-Min 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 407 KB

## Abstract Deep vein thrombosis associated with advanced cancer is known as Trousseau's syndrome. We hypothesized that thrombin, an activator of protease‐activated receptor (PAR)‐1 and PAR‐4 contributes to tumor metastasis. In this study, we demonstrated that thrombin and the PAR‐1 activating pept