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Hypoxia-inducible factor-1 and activator protein-1 modulate the upregulation of CYP3A6 induced by hypoxia

✍ Scribed by Caroline Fradette; Patrick du Souich


Book ID
110008074
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
361 KB
Volume
140
Category
Article
ISSN
0007-1188

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## Abstract Quercetin, a ubiquitous bioactive plant flavonoid, has been shown to inhibit the proliferation of cancer cells and induce the accumulation of hypoxia‐inducible factor‐1Ξ± (HIF‐1Ξ±) in normoxia. In this study, under hypoxic conditions (1% O~2~), we examined the effect of quercetin on the i