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Hypoxia inducible factor-1 alpha expression in human normal and osteoarthritic chondrocytes

✍ Scribed by Ibsen B. Coimbra; Sergio A. Jimenez; David F. Hawkins; Sonsoles Piera-Velazquez; David G. Stokes

Book ID
113732130
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
384 KB
Volume
12
Category
Article
ISSN
1063-4584

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This study tested the effect of fluid-induced shear on interleukin-6 expression in normal human articular chondrocytes in vitro. As determined by Northern blot analysis, interleukin-6 mRNA expression occurs in chondrocytes from osteoarthritic cartilage but not in normal chondrocytes. Applying fluid-