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Hypoxia induces transcription of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4 gene via hypoxia-inducible factor-1α activation

✍ Scribed by Oleksandr Minchenko; Iryna Opentanova; Dmytro Minchenko; Tsutomu Ogura; Hiroyasu Esumi

Book ID
116464840
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
227 KB
Volume
576
Category
Article
ISSN
0014-5793

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## Abstract Prostaglandin F2α (PGF2α) is a potent paracrine inhibitor of adipocyte differentiation. Here we show that treatment of differentiating 3T3‐L1 preadipocytes with PGF2α induces the expression of DEC1, a transcriptional repressor that has previously been implicated in the inhibition of adi