✦ LIBER ✦

Hypoxia in prostate cancer: A powerful shield against tumour destruction?

✍ Scribed by L. Marignol; M. Coffey; M. Lawler; D. Hollywood

Book ID: 116395191
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 774 KB
Volume: 34
Category: Article
ISSN: 0305-7372
DOI: 10.1016/j.ctrv.2008.01.006

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## Abstract ## Background We proposed to exploit hypoxia‐inducible factor (HIF)‐1α overexpression in prostate tumours and use this transcriptional machinery to control the expression of the suicide gene cytosine deaminase (CD) through binding of HIF‐1α to arrangements of hypoxia response elements.