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Hypoxia in larynx carcinomas assessed by pimonidazole binding and the value of CA-IX and vascularity as surrogate markers of hypoxia

โœ Scribed by Ilse J. Hoogsteen; Jasper Lok; Henri A.M. Marres; Robert P. Takes; Paul F.J.W. Rijken; Albert J. van der Kogel; Johannes H.A.M. Kaanders


Book ID
116430133
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
651 KB
Volume
45
Category
Article
ISSN
0959-8049

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## Abstract The presence of hypoxia in tumours results in the overexpression of certain genes, which are controlled via the transcription factor HIFโ€1. Hypoxic cells are known to be radioresistant and chemoresistant, thus, a reliable surrogate marker of hypoxia is desirable to ensure that treatment