Hypoxia and PDGF have a synergistic effect that increases the expression of the angiogenetic peptide vascular endothelial growth factor in Achilles tendon fibroblasts

Cyclic strain influences the expression

Cyclic strain influences the expression of the vascular endothelial growth factor (VEGF) and the hypoxia inducible factor 1 alpha (HIF-1α) in tendon fibroblasts

✍ Wolf Petersen; Deike Varoga; Thore Zantop; Joachim Hassenpflug; Rolf Mentlein; T 📂 Article 📅 2004 🏛 Elsevier Science 🌐 English ⚖ 785 KB

## Abstract Neovascularization is involved in beneficial and detrimental processes of tendon pathology. We investigated the influence of repetitive motion on the expression of the most important angiogenic factor, the vascular endothelial growth factor (VEGF) in the 3T3 NIH fibroblast cell line an