Defective insulin signaling pathway and
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C.G. Jolivalt; C.A. Lee; K.K. Beiswenger; J.L. Smith; M. Orlov; M.A. Torrance; E
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Article
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2008
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John Wiley and Sons
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English
β 370 KB
## Abstract We have evaluated the effect of peripheral insulin deficiency on brain insulin pathway activity in a mouse model of type 1 diabetes, the parallels with Alzheimer's disease (AD), and the effect of treatment with insulin. Nine weeks of insulinβdeficient diabetes significantly impaired the