Hypoxia-activated tumor pathways of angiogenesis and pH regulation independent of anemia in head-and-neck cancer
β Scribed by Michael I Koukourakis; Alexandra Giatromanolaki; Efthimios Sivridis; Jaromir Pastorek; Ilias Karapantzos; Kevin C Gatter; Adrian L Harris
- Book ID
- 108148299
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 383 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0360-3016
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## Abstract ## BACKGROUND: Hypoxia is an important mechanism of treatment resistance in head and neck squamous cell carcinoma (HNSCC). MicroRNAs are short noncoding RNAs that regulate multiple mRNAs and are frequently dysregulated in cancer. The authors have investigated the role of 3 microRNAs, i
## Background: Hypoxia-inducible factor 1alpha (hif-1alpha) and hif-2alpha are essential regulatory proteins for the adaptation of tumor cells to hypoxia, and they stimulate angiogenesis through activation of the vascular endothelial growth factor (vegf) gene. ## Methods: Hif-1alpha and hif-2alph