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Hypoxanthine phosphoribosyltransferase activity in normal, developing, and neoplastic tissues of the rat

✍ Scribed by Robert M. Wohlhueter

Book ID: 113145641
Publisher: Elsevier Science
Year: 1975
Weight: 861 KB
Volume: 11
Category: Article
ISSN: 0014-2964
DOI: 10.1016/0014-2964(75)90147-4

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## Abstract Nine independently derived clones of mutagenized rat hepatoma cells selected for resistance to 6‐mercaptopurine (6‐MP) or 6‐thioguanine (6‐ThioG) have been isolated. Each has severely reduced catalytic activity of hypoxanthine‐guanine phosphoribosyltransferase (HPRT) and seven of them p