A case of disseminated Hodgkin's disease and hypouricemia is reported. Serum uric acid values prior to chemotherapy ranged from 0.7 to 1.7 mg% i n association with a markedly elevated uric acid clearance. The etiology of the defect i n renal handling of uric acid i n this syndrome remains to b e elucidated.
YPOUKICEMIA HAS RECENTLY I E E N DE-
H scribed in two cases of Hodgkin's disease.' I n both cases, markedly elevated uric acid clearances were present, presumably due to an increase in renal tubular secretion of uric acid. Following chemotherapy, the abnormal uric acid clearance returned to normal in both cases.
A third case of Hodgkin's disease with liypouricemia and elevated uric acid clearances is described in the following report.
CASE REPORT
A 47-year-old Caucasian male was transferred to the Upstate Medical Center on the 4th of August, 1972. A diagnosis of "lymphosarcoma" had been made at a nearby hospital by biopsy of a right inguinal node 3 weeks prior to his present admission. T h e patient gave a 3-6 month history of anorexia, 40 lb weight loss, light-headedness, weakness, and enlarging right inguinal nodes. He had received no therapy prior to his transfer. T h e patient denied fever, pruritus, alcohol intolerance, or night sweats. His past medical history revealed heavy ethanol ingestion. There was no significant drug or medication history. Prior to transfer a barium enema, metastatic survey, and lumbar puncture revealed no abnormalities. In addition, a lymphangiogram showed complete obstruction of the lymphatic From the Section of