𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Hypothyroidism in older patients with head and neck cancer after treatment with radiation: A population-based study

✍ Scribed by Grace L. Smith; Benjamin D. Smith; Adam S. Garden; David I. Rosenthal; Steven I. Sherman; William H. Morrison; David L. Schwartz; Randal S. Weber; Thomas A. Buchholz

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
108 KB
Volume
31
Category
Article
ISSN
1043-3074

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Background

In patients with head and neck cancer, radiation treatment (RT) is a risk factor for hypothyroidism. However, the specific magnitude of risk after RT in older patients is not known.

Methods

We identified 5916 patients (age > 65 years) from SEER‐Medicare diagnosed with head and neck cancer from 1992 to 2002. Proportional hazards models compared hypothyroidism risk after any RT versus surgery alone.

Results

In patients treated with RT, 5‐year incidence of hypothyroidism was 20% and 10‐year incidence was 59%; in patients treated with surgery alone, incidence was 7% and 39% (p < .001). Patients treated with RT had increased adjusted risk (hazard ratio [HR] = 2.14; 95% confidence interval [CI] = 1.74–2.62), persisting for up to 10 years of follow‐up (HR = 1.85, 95% CI = 1.39–2.44 from 5 to 10 years).

Conclusion

In older patients with head and neck cancer, RT is associated with elevated hypothyroidism risk. As onset may be delayed for years, patients may require lifelong thyroid function screening after treatment. Β© 2009 Wiley Periodicals, Inc. Head Neck, 2009

πŸ“œ SIMILAR VOLUMES

Risk of hypothyroidism in older breast c
Risk of hypothyroidism in older breast cancer patients treated with radiation
✍ Grace L. Smith; Benjamin D. Smith; Sharon H. Giordano; Ya Chen T. Shih; Wendy A. πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 101 KB πŸ‘ 2 views

## Abstract ## BACKGROUND. Hypothyroidism is a potential complication after radiation therapy (RT) when treatment fields include the thyroid. The authors assessed risk of hypothyroidism in breast cancer patients who were receiving RT to a supraclavicular field, which typically includes a portion o

Driving behaviors in patients with head
Driving behaviors in patients with head and neck cancer during and after cancer treatment: A preliminary report
✍ Hon K. Yuen; Marion B. Gillespie; Terry A. Day; Larissa Morgan; Jerry K. Burik πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 115 KB πŸ‘ 1 views

## Abstract ## Background. The purpose of this study was to explore the driving behaviors of head and neck cancer patients during and after cancer therapy. ## Methods. Eighty‐three patients completed a questionnaire related to driving behaviors. ## Results. The survey revealed that 67.5% of re

Eating ability in head and neck cancer p
Eating ability in head and neck cancer patients after treatment with chemoradiation: A 12-month follow-up study accounting for dropout
✍ Alfred W. Rademaker; Edward F. Vonesh; Jeri A. Logemann; Barbara Roa Pauloski; D πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 91 KB πŸ‘ 1 views

## Abstract ## Background. Head and neck cancer patients treated with chemoradiation have difficulty eating a normal diet. This study was designed to characterize eating ability over 12 months after chemoradiation treatment. Analyses take patient dropout into account. ## Methods: Two hundred fif

Outcomes after the use of gastrostomy tu
Outcomes after the use of gastrostomy tubes in patients whose head and neck cancer was managed with radiation therapy
✍ Julie A. Ames; Lucy Hynds Karnell; Anjali K. Gupta; Todd C. Coleman; Michael P. πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 140 KB πŸ‘ 1 views

## Abstract ## Background The purpose of this study was to examine the effect of continued oral intake and duration of gastrostomy tube placement on posttreatment nutritional outcomes in patients being irradiated for head and neck cancer. ## Methods Factors associated with continued oral intake