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Hypothesis: The telophase disc: Its possible role in mammalian cell cleavage

✍ Scribed by Robert L. Margolis; Paul R. Andreassen

Book ID
102760903
Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
941 KB
Volume
15
Category
Article
ISSN
0265-9247

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✦ Synopsis

Abstract

The molecular signals that determine the
position and timing of the furrow that forms during mammalian cell
cytokinesis are presently unknown. It is apparent, however, that
these signals are generated by the mitotic spindle after the onset of
anaphase. Recently we have described a structure that bisects the
cell during telophase at the position of the cytokinetic furrow. This
structure, the telephase disc, appears to the templated by the motitc spindle during anaphase, and precedes the formation of the cytokinetic furrow. The relationship of the telephase disc to the myosin and actin based furrowing mechanism is discussed here. We propose that the telophase disc may determine the position and timing of cleavage by recruitment and alignment of myosin.

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