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Hypothesis: Homozygosity in tourette syndrome

✍ Scribed by Comings, David E. ;Comings, Brenda G. ;Knell, Ellen

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 962 KB
Volume: 34
Category: Article
ISSN: 0148-7299
DOI: 10.1002/ajmg.1320340318

No coin nor oath required. For personal study only.

✦ Synopsis

We review evidence suggesting that many individuals with Tourette syndrome (TS) may be homozygous for a "Tourette syndrome" gene. This is based on experience with pedigrees on 1,200 TS families, comparison of the occurrence of tics or associated behaviors such as obsessive-compulsive behavior, panic attacks, attention deficit hyperactivity disorder, and/or severe alcohol or drug abuse, on both the maternal and paternal side in 170 TS families compared to control families, biochemical studies of blood serotonin and tryptophan levels, and other evidence. These observations suggest the inheritance in TS may be best described as semi-dominant, semi-recessive. Some of the implications of this proposal are discussed.

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