Hypothalamo-pituitary-adrenal axis dysfunction as a contributory factor to chronic pain and depression

Moderation of psychosocial risk factors

Moderation of psychosocial risk factors through dysfunction of the hypothalamic–pituitary–adrenal stress axis in the onset of chronic widespread musculoskeletal pain : Findings of a population-based prospective cohort study

✍ J. McBeth; A. J. Silman; A. Gupta; Y. H. Chiu; D. Ray; R. Morriss; C. Dickens; Y 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 177 KB 👁 2 views

Objective. To test the hypothesis that abnormalities in the hypothalamic-pituitary-adrenal (HPA) stress-response system would act as an effect moderator between HPA function and the onset of chronic widespread pain (CWP). Methods. We conducted a population-based prospective cohort study. Current pa