Hypotensive effect of O-methylisothalicberine, a bisbenzylisoquinoline alkaloid isolated from Berberis chilensis on normotensive rats
✍ Scribed by J. L. Martínez; R. Torres; M. A. Morales
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 97 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0951-418X
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✦ Synopsis
O-Methylisothalicberine (O-MI
) is a bisbenzylisoquinoline alkaloid isolated from Berberis chilensis, structurally similar to alkaloids previously described in the literature as calcium antagonists of natural origin (berbamine, tetrandrine, antioquine, 7-O-demethylisothalicberine and others). O-MI caused a significant reduction of mean arterial pressure (MAP) in normotensive anaesthetized rats. Doses of 1.0; 2.5; 5.0; 7.5 and 10.0 mg/kg were administered via the femoral vein. MAP was reduced by 5.8%; 10.1%; 35.6%; 67.9% and 60.5% respectively. The onset of hypotensive action was 5 s after 5 mg/kg i.v. and the effect lasted for about 120 s. O-MI exhibited an LD 50 of 5 mg/mL towards the brine shrimp (Artemia salina).