Hypotensive Activity of Lannea coromandelica Bark Extract

✍ Scribed by Surjeet Singh; G. B. Singh

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 182 KB
• Volume: 10
• Category: Article
• ISSN: 0951-418X
• DOI: 10.1002/(sici)1099-1573(199608)10:5<429::aid-ptr862>3.0.co;2-2

✦ Synopsis

An ethanol extract of hnnea coromandelica bark (ELC) showed hypotensive activity in anaesthetized dogs and rats. On intravenous administration (i.v.) at a dose range of 5-100 mg/kg in dogs and 1-25 mgkg in rats it produced a mild to marked decrease in the arterial blood pressure in a dose dependent manner. The effect did not alter after cholingergic, histaminergic, adrenergic and ganglion receptor blockade. The hypotension was also unchanged in vagotomized and eviscerated dogs, whereas there was a slight increase in hypotension in the spinal preparation. It produced dose related decreases in heart rate, without any effect on respiratory rate.