Hyporesponsiveness of lymphocytes to virus antigens in rheumatoid arthritis

✍ Scribed by Robert E. Wolf

• Publisher: John Wiley and Sons
• Year: 1978
• Tongue: English
• Weight: 379 KB
• Volume: 21
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780210211

✦ Synopsis

Abstract

The immune response of peripheral blood lymphocytes to measles, rubella, parainfluenza types 1, 2, and 3 RNA virus antigens, and to varicella‐zoster and herpes virus type 1 DNA virus antigens was evaluated in 14 patients with rheumatoid arthritis (RA) and 14 matched controls by assessing ^3^H‐thymidine incorporation. The results demonstrated hyporesponsivenss of lymphocytes from RA patients to virus antigens and phytohemag‐glutinin (PHA), which did not appear to be nonspecific because of a lack of correlation between response to virus antigens and response to mitogens. The pattern of decreased responsiveness was suggestive of a relative restriction of hyporesponsiveness to RNA virus antigens.