Hypoplasia of the bone marrow in rats following removal of the parathyroid glands

✍ Scribed by R. H. Rixon; J. F. Whitfield

• Publisher: John Wiley and Sons
• Year: 1972
• Tongue: English
• Weight: 845 KB
• Volume: 79
• Category: Article
• ISSN: 0021-9541
• DOI: 10.1002/jcp.1040790304

✦ Synopsis

Removal of the parathyroid glands caused a marked and permanent lowering of the mitotic activity i n rat bone marrow, which was followed by a pronounced decline (ca. 40%) i n the size of the marrow's nucleated cell population. These changes occurred only when the hypocalcemia induced by the lack of parathyroid hormone (PTH) was maintained by feeding the animals a calcium deficient diet. Since the overall marrow hypoplasia was almost entirely due to strikingly large reductions (ca. 70%) i n the size of the erythroid and lymphoid subpopulations, it is concluded that PTH and calcium are major physiological regulators of the proliferation of erythroid and lymphoid cells.