In vitro metabolism of 10-(3-chloropheny
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Shmuel Zbaida; Yancy Du; Daniel Shannon; Donald Laudicina; C. Mohan Thonoor; Kwo
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Article
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1998
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John Wiley and Sons
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English
⚖ 405 KB
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The metabolism of SCH 40120, which is the clinically effective antipsoriatic drug 10- (3chlorophenyl)-6,8,9,10-tetrahydrobenzol[b][1,8]naphthyridin-5(7H)-one, was determined in vitro. Rat, dog, cynomolgus monkey, and human liver slices hydroxylated the aliphatic, cyclohexenyl ring of the drug and co