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Hypoosmotic volume regulation in bivalves: Protein kinase C and amino acid release

✍ Scribed by Deaton, Lewis E.

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
570 KB
Volume
268
Category
Article
ISSN
0022-104X

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✦ Synopsis

Abstract

Phorbol esters potentiate the release of free amino acids from isolated ventricles and gills of the mussel, Geukensia demissa, when the tissues are incubated in hypoosmotic seawater. Phorbol esters do not affect the release of amino acids from tissues in isosmotic seawater. Inhibitors of protein kinase C depress the release of amino acids from isolated ventricles in hypoosmotic seawater by 25–30%. Calmodulin antagonists did not inhibit the efflux of amino acids from isolated ventricles in hypoosmotic seawater.

The level of inositol 1,4,5‐triphosphate does not change in isolated ventricles incubated in either hypoosmotic or isosmotic seawater. In contrast, there is a transient increase in the level of diacylglycerol in ventricles exposed to hypoosmotic seawater. The increase is detectable 0.5 min after transfer of the tissue to hypoosmotic seawater; 2 min after transfer, there is no difference between tissues incubated in isosmotic and hypoosmotic media.

These results suggest that protein kinase C plays a role in the modulation of the release of amino acids from ventricle and gill cells in G. demissa. Β© 1994 Wiley‐Liss, Inc.

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