We characterized morphological effects of the endogenous excitotoxin, glutamate in ex vivo retinal segments prepared from 30-day-old rats. Initial changes induced by glutamate consisted of reversible, sodium-dependent Mu ¨ller cell swelling. This glial swelling was mimicked by glutamate transport su
Hypoosmotic and glutamate-induced swelling of bipolar cells in the rat retina: comparison with swelling of Müller glial cells
✍ Scribed by Vogler, Stefanie; Grosche, Antje; Pannicke, Thomas; Ulbricht, Elke; Wiedemann, Peter; Reichenbach, Andreas; Bringmann, Andreas
- Book ID
- 120458952
- Publisher
- John Wiley and Sons
- Year
- 2013
- Tongue
- English
- Weight
- 542 KB
- Volume
- 126
- Category
- Article
- ISSN
- 0022-3042
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## Abstract Glutamate is thought to participate in a variety of retinal degenerative disorders. However, when exposed to glutamate at concentrations up to 1 mM, ex vivo rat retinas typically exhibit Müller cell swelling, but not excitotoxic neuronal damage. This Müller cell swelling is reversible f
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