Hyponatremia and cerebral infarction in patients with ruptured intracranial aneurysms: Is fluid restriction harmful?
✍ Scribed by Dr E. F. M. Wijdicks; M. Vermeulen; A. Hijdra; J. van Gijn
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- English
- Weight
- 352 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0364-5134
No coin nor oath required. For personal study only.
✦ Synopsis
We studied retrospectively the relationship between hyponatremia and cerebral infarction in 134 consecutive patients with aneurysmd subarachnoid hemorrhage. In 44 patients sodium levels fell below 135 mmoVL on at least two consecutive days between the second and the tenth day after the hemorrhage. Twenty-five of these patients fulfilled the criteria for the syndrome of inappropriate secretion of antidiuretic hormone. Cerebral infarction developed in 27 of the 44 patients with hyponatremia and in 19 of the 30 patients with normal serum sodium levels Cp < 0.001). Cerebral infarctions were more often fatal in patients with hyponatremia Cp < 0.01).
Twenty-six of the 44 patients had been treated with fluid restriction to correct the serum sodium levels, and infarctions developed in 2 1. Fluid restriction to correct hyponatremia appears to be potentially dangerous in patients with aneurysmal subarachnoid hemorrhage.