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Hyponatraemia due to amantadine hydrochloride and L-dopa/carbidopa

✍ Scribed by G.J. Lammers; Rac Roos

Book ID
119067213
Publisher
The Lancet
Year
1993
Tongue
English
Weight
169 KB
Volume
342
Category
Article
ISSN
0140-6736

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Administration of L-dopa (L-3,4-dihydroxyphenylalanine) (200 mg/kg p.o.) to rats produced elevated plasma and muscle concentrations of both L-dopa and 3-O-methyldopa (3-OMD). This effect was potentiated by simultaneous administration of carbidopa (25 mg/kg p.o.). Both L-dopa and 3-OMD accumulated in