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Hypomethylation and increased gene expression of p16INK4a in primary and metastatic breast carcinoma as compared to normal breast tissue

✍ Scribed by Zee, Kimberly J Van; Calvano, Jacqueline E; Bisogna, Maria


Book ID
110061311
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
359 KB
Volume
16
Category
Article
ISSN
0950-9232

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## Abstract The interplay between cancer cells and the normal surrounding tissue is believed to influence the biological behavior of the tumor. However, the presence of multiple cell types within the prelevated tumor specimen may attenuate changes that occur specifically in the malignant cells with