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Hypomelanosis of Ito: No entity, but a cutaneous sign of mosaicism

✍ Scribed by K�ster, Wolfgang; K�nig, Arne

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
9 KB
Volume
85
Category
Article
ISSN
0148-7299
DOI
10.1002/(sici)1096-8628(19990806)85:4<346::aid-ajmg7>3.0.co;2-1

No coin nor oath required. For personal study only.

✦ Synopsis

Hypomelanosis of Ito is a neurocutaneous phenotype comprising pigmentary anomalies, neurological defects, structural malformations, and chromosomal abnormalities. It has been described as a distinct multisystem birth defect or, more specifically, as a neurocutaneous syndrome. The main purpose of this study is to provide evidence that this disorder does not exist as a syndrome. Rather, it is a causally nonspecific pigmentary disorder caused by genetic mosaicism.

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