Hypoglycaemic Effects of Shokatsu-Cha (Xiao-Ke-Ca ) in Streptozotocin-induced Diabetes Mellitus

✍ Scribed by Fujiko Sanae; Ken-ichi Miyamoto; Hiroyuki Sawanishi; Haruhisa Kizu; Ysuyoshi Tomimori; Jian-ning Sun; Xiu-hua Sun

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 355 KB
• Volume: 10
• Category: Article
• ISSN: 0951-418X
• DOI: 10.1002/(sici)1099-1573(199603)10:2<127::aid-ptr784>3.0.co;2-q

✦ Synopsis

Shokatsu-cha is a novel formula for diabetic mellitus based on the traditional Chinese medicine and composed of Dwscoreae rhizoma, Adenophorae radix, Rehmanniae radix, Anemarrhenae rhuoma, Pkrtycodi radir, Salviue m&rrhizae radix, Epimedu folium and Lycii fructus. The hypoglycaemic effect of Shokutsu-cha was evaluated in streptozotocin (STZ)-induced diabetic mice and rats. When orally administered once a day for 10 days to the mice intraperitoneally iqjected with STZ, the ShoRatsu-cha extract suppressed the increase of the blood glucose level during administration. In the in situ intestine circulation method, the Shokatsu-cha extract and its ethanoleluted fraction inhibited the glucose absorption in STZ-induced diabetic rats. The ethanolsluted fraction also inhibited the increase of blood glucose level in an oral glucose tolerance test using diabetic mice. This study indicates that a part of the hypoglycaemic effect of Shokatsu-cha is based on its inhibitory action on intestinal glucose absorption in diabetes.