Hypoglycaemic Agent(s) in Leaves of Elaeophorbia drupifera

✍ Scribed by A. E. Eno; E. H. Itam

• Book ID: 101286480
• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 216 KB
• Volume: 10
• Category: Article
• ISSN: 0951-418X
• DOI: 10.1002/(sici)1099-1573(199612)10:8<680::aid-ptr881>3.0.co;2-c

✦ Synopsis

Male white Wistar rats (250-300 g), after an overnight fast, were treated with a crude extract (20 mgntg oral) from the leaves of E. drupiferu. The extract was administered 2 h before and 2 h after either an oral glucose load (3 gkg) or a subcutaneous injection of adrenaline (0.01 mg/kg). The results showed that the extract reduced the blood glucose levels in rats that received the extract 2 h before glucose and adrenaline administration by about 34.3% and 35.2%, respectively. For the group that received the extract 2 h after glucose and adrenaline administration, the blood glucose levels were reduced by about 52.8% and 29.7%, respectively.

Comparison was made between the action of the extract and a known hypoglycaemic drugglibenclamide (0.29 mg/kg oral). The extract (20 mg/kg oral) was found to be faster and more effective than glibenclamide in lowering the blood glucose levels in fasting rats.