Surveillance colonoscopy and biopsy are inaccurate methods of predicting the likelihood of ulcerative colitis patients to develop colon carcinoma. We examined uPA and PAI-1 as potential markers for assessing these patients and those with familial polyposis who are at risk of developing colon cancer.
Hypofibrinolysis in patients with hypercoagulability: The roles of urokinase and of plasminogen activator inhibitor
β Scribed by Herbert K. F. Lau; Jerome M. Teitel; To Cheung; Sam K. P. Kung; M. Bernadette Garvey
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 545 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0361-8609
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## BACKGROUND. Urokinase plasminogen activator (u-PA) plays a key role in the metastatic process by promoting plasmin mediated tissue degradation. Metastatic cell invasion requires localized proteolysis, which may be directed by u-PA receptor. The binding of u-PA and PAI-1 to the u-PA-receptor may
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## Abstract Metastatic growth and invasion by colon cancer cells in the liver requires the ability of the cancer cells to interact with the new tissue environment. Plasmin(ogen) is activated on cell surfaces by urokinaseβtype PA (uPA), and is regulated by uPAR and plasminogen activator inhibitorβ1