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Hypocholesterolemic agents II: Inhibition of β-hydroxy-β-methylglutaryl coenzyme a reductase by arylalkyl hydrogen succinates and glutarates

✍ Scribed by Marvin R. Boots; Sharon G. Boots; Carole M. Noble; Kenneth E. Guyer

Publisher: John Wiley and Sons
Year: 1973
Tongue: English
Weight: 498 KB
Volume: 62
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600620620

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## Abstract Our earlier studies demonstrated that the β‐hydroxy‐β‐methylglutaryl coenzyme A (HMG CoA) reductase gene is hypomethylated and overexpressed in hepatic nodules initiated by 1,2‐dimethylhydrazine (1,2‐DMH). The study presented here examined whether the pattern of DNA methylation of the H