Hypnoticlike effects of cannabidiol in the rat

✍ Scribed by Jaime M. Monti

• Book ID: 104787246
• Publisher: Springer
• Year: 1977
• Tongue: English
• Weight: 198 KB
• Volume: 55
• Category: Article
• ISSN: 0033-3158
• DOI: 10.1007/bf00497858

✦ Synopsis

The actions of cannabidiol (CBD), one of the cannabis constituents, were assessed on the sleep-wakefulness cycle of male Wistar rats. During acute experiments, single doses of 20 mg/kg CBD decreased slow-wave sleep (SWS) latency. After 40 mg/kg SWS time was significantly increased while wakefulness was decreased. REM sleep was not significantly modified. Following the once-daily injections of 40 mg/kg CBD for a period of 15 days, tolerance developed to all the above-mentioned effects.