Hyperventilation zur Vermeidung von Störungen der exkretorischen Leberfunktion im Initialstadium der Nitrostigmin-(E 605 forte®-) Vergiftung an Ratten
✍ Scribed by S. Okonek; G. Boelcke
- Publisher
- Springer-Verlag
- Year
- 1972
- Tongue
- English
- Weight
- 800 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0340-5761
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✦ Synopsis
The influence of hypoxemia and respiratory acidosis on bile flow, hepatic elimination of bilirubin and the concentration of conjugated and unconjugated plasma bilirubin was studied in nitrostigmine (E 605 forte | ) poisoned rats. The combination of hypoxemia and respiratory acidosis in rats poisoned with nitrostigmine results in a significant decrease in bile flow and hepatic clearance of bilirubin. Nitrostigmine poisoning (4 ~l/kg b.w. E 605 forte | ) does not adversely affect hepatic excretory function if arterial pO~ is maintained within the normal range by artificial hyperventilation (slight rise in arterial pH). The consequences of these studies for the treatment of human nitrostigmine intoxication are discussed.