Hypervariable region 1 quasispecies in chronic hepatitis C patients: influence of genotype
โ Scribed by Tarik Asselah; Michelle Martinot-Peignoux; Dominique Cazals-Hatem; Nathalie Boyer; Dominique Valla; Claude Degott; Patrick Marcellin
- Book ID
- 119527227
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 148 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0168-8278
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## Abstract The hypervariable region 1 (HVR1) has been most reliably identified in the genome of HCV genotype 1 isolates and thought to possibly play a role in immune evasion and development of chronic infection. There are few studies, however, of other HCV genotypes to determine if they also have
that antibodies to HCV envelope glycoproteins may have a We studied the heterogeneity in the E2/NS1 hypervarineutralizing effect, 4,5 and the genetic drift in HVR1 is thought able region 1 of the hepatitis C virus (HCV) genome in to provide HCV with a better chance for adaptation to imrelation to th