Hypertrophic response to angiotensin II is mediated by protein kinase D-extracellular signal-regulated kinase 5 pathway in human aortic smooth muscle cells

The p38 mitogen-activated protein kinase

The p38 mitogen-activated protein kinase pathway is involved in the regulation of heme oxygenase-1 by acidic extracellular pH in aortic smooth muscle cells

✍ Jason Guan; Xinqi Wu; Elena Arons; Helen Christou 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 249 KB 👁 2 views

## Abstract Extracellular acidosis (EA) regulates Heme Oxygenase‐1 (HO‐1) expression in vascular smooth muscle cells via transcriptional and posttranscriptional mechanisms but the signaling pathways involved are not known. We examined the role of Mitogen‐Activated Protein Kinase (MAPK) pathways in