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Hypertonicity enhances expression of functional Na+/K+/2Cl− cotransporters in Ehrlich ascites tumour cells

✍ Scribed by Bo Skaaning Jensen; Else K Hoffmann

Book ID
117048793
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
340 KB
Volume
1329
Category
Article
ISSN
0005-2736

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Regulatory volume increase in Ehrlich as
Regulatory volume increase in Ehrlich ascites tumor cells is mediated by the 1Na ∶ 1K ∶ 2Cl cotransport system
✍ Charles Levinson 📂 Article 📅 1992 🏛 Springer 🌐 English ⚖ 699 KB

After swelling in hyposmotic solution, Ehrlich ascites tumor cells shrink towards their original volume. Upon restoration of isosmolality (300 mOsM) the cells initially shrink but subsequently recover volume. This regulatory volume increase (RVI) is completely blocked when [Na+]o or [Cl-]o is reduce