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Hypertonic saline and recombinant human DNase: a randomised cross-over pilot study in patients with cystic fibrosis

โœ Scribed by Manfred Ballmann; Horst von der Hardt


Book ID
118640050
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
63 KB
Volume
1
Category
Article
ISSN
1569-1993

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Cystic fibrosis is characterized by the accumulation of thick viscous purulent secretions. Recombinant human deoxyribonuclease I (rhDNase) breaks down extracellular DNA, which contributes to the increased viscosity of sputum. A multinational, open-label study was conducted in 974 cystic fibrosis pat