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Hyperthermic stress modulates the functions of rat liver glucocorticoid receptor

✍ Scribed by Gordana Matić; Jasmina Kipić; Biljana Ristić; Jadranka Dundjerski; Divna Trajković

Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
607 KB
Volume
19
Category
Article
ISSN
1065-6995

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✦ Synopsis

ABSTRACT

A mild whole body hyperthermic stress causes a rapid and reversible reduction of rat liver glucocorticoid receptor (GR) binding capacity and affects the stability of the GR‐DNA complexes formed after thermal transformation of the receptor. These changes appear to be physiologically relevant, since they are accompanied by a decrease in dexamethasone induction of hepatic tyrosine aminotransferase (TAT). In spite of the decreased rate of the GR degradation in liver cytosol of hyperthermic as compared to control rats, the total amount of the GR and its proteolytic products recognized by BuGR2 monoclonal antibody was found to be lower in the former cytosol, but higher in the respective nuclei.

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## Abstract The presence of glucocorticoid receptors (GR) in rat liver nuclei over a 24 h time period following hyperthermic stress at 41 °C was immunocytologically studied using unfixed nuclear smears. Liver nuclei in unstressed animals were found to be immunonegative for GR. However, intense GR i