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Hyperthermic modification of cyclophosphamide metabolism in rat hepatic microsomes and liver slices

✍ Scribed by Ronald E. Clawson; Merrill J. Egorin; Bonnie M. Fox; Louis A. Ross; Nicholas R. Bachur

Book ID
118940721
Publisher
Elsevier Science
Year
1981
Tongue
English
Weight
281 KB
Volume
28
Category
Article
ISSN
0024-3205

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The metabolism of cyclophosphamide-44, (2-[bis(2-chloroethyI)amino]-tetrahydro-4,4-dideuterio-2H-1,3,2-oxazaphosphorine 2-oxide), was studied. The first detectable metabolite was a hydroxy derivative which was trapped with ethanol. Mass spectrometry of the resulting two ethowy derivatives and of the