We examined the effectiveness of hypertensive intra-arterial chemotherapy for endometrial carcinoma using transvaginal Doppler ultrasound and magnetic resonance imaging. Angiotensin 11, 100 mg cisplatin, and 40 mg doxorubicin were prescribed for 8 patients with endometrial carcinoma (3 stage Ia; 3 stage Ib; 2 stage 11). The resistance index (RI) was obtained for intratumoral blood flow velocity waveforms by transvaginal Doppler ultrasound and changes in RI (ARI: differences before and after chemotherapy) were calculated. The tumor volume (TV) was also evaluated, based on the T2-weighted image of magnetic resonance imaging (MRI). The decrease in tumor size [DR-T: (TV before chemotherapy -TV after chemotherapy) / TV before chemotherapy x 1001 was determined. RI measurements did not correlate with TV, either before or after chemotherapy. The ARI varied from 0.007 to 0.615 (mean: 0.207) and DR -T varied from 20.1% to 65.0% (mean: 45.5%). The correlation between ARI and DR -T [DR -T = 23.5 + 167.2 (ARI) -165.6 (ARI)'; R2 = 0.772, p < 0.051 was significant. Therefore, we confirmed the effectiveness of hypertensive intra-arterial chemotherapy for endometrial carcinoma using both transvaginal Doppler ultrasound and MRI.